Parts of the US face a "significant Arctic outbreak" for the Thanksgiving holiday, which includes some of the country's busiest travel days of the year.
The National Weather Service said angerously cold wind chills are anticipated over the northern Plains on Thursday.
Meanwhile, parts of the north-east including New England could see heavy snow, and the East Coast is expected to be hit by thunderstorms.
The severe conditions come in a week expected to set records for Thanksgiving travel. Thousands of flights were delayed and dozens cancelled on Wednesday, according to tracking site FlightAware.
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