Puerto Rico and El Salvador have shown interest in hosting the 2022 Central American and Caribbean Games, following Panama's withdrawal. Due to the COVID-19 pandemic, the southern-most Central American nation pulled out of its hosting duties in July, leaving Centro Caribe Sports to look for a new bidder.
Centro Caribe Sports president Luis Mejia released the information about the two interested parties after the deadline for submitting a bid had passed. The two applications submitted were for the Puerto Rican city of Mayaguez and El Salvador's capital San Salvador.
Following the news, Centro Caribe Sports first vice-president Jimena Saldaña of Mexico was temporarily appointed president of the Future Venues Commission.
This is due to the incumbent president, Sara Rosario, being the president of the Puerto Rico Olympic Committee and Centro Caribe Sports needing to avoid a conflict of interest with Mayaguez as a bid city.