Puerto Rico Governor Wanda Vazquez declared a state of emergency and activated the National Guard on Tuesday after a series of earthquakes, including one of magnitude 6.4 that was the most powerful to strike the Caribbean island in 102 years.
Miss Vazquez told a news conference that the quakes killed at least one person, triggered a protective power outage across the entire island and cut off drinking water to 300,000 customers.
Officials said at least 346 people were left homeless as homes were flattened, mostly in the south of the island.
Many damaged buildings sat next to piles of rubble.
The declaration of emergency will facilitate federal financial aid for the U.S. territory.
Miss Vazquez said she had been in contact with the Federal Emergency Management Agency (FEMA).
Several members of Congress including Florida's two U.S. senators and Puerto Rico's non-voting member of the House of Representatives appealed to U.S. President Donald Trump for aid.