It is unclear what led to the crash, who was aboard the plane or if there are any survivors.
A small plane has crashed into several buildings in north-east Philadelphia, setting homes and vehicles ablaze, and reportedly injuring people on the ground.
Multiple people were aboard the plane when it crashed on Friday evening, officials said.
Emergency crews rushed to the scene during evening rush hour.
It is unclear what led to the crash, who was aboard the plane or if there are any survivors.
The crash happened just blocks from the Roosevelt Mall, a three-story shopping centre in a densely populated part of the Pennsylvania city, according to BBC's US partner CBS News.
The area where the crash occurred is filled with terraced housing and shops.
Disturbing video of the incident online show the plane coming down quickly and sparking a huge fireball that rocketed into the sky.
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