Up to sports time, Thompson-Herah's agent Marvin Anderson could not be reached for comment.
Coach Osbourne declined to field questions when she answered her telephone late Monday night.
She only noted that she was not accepting any media to her training base.
However, Radio Jamaica Sports sources, who spoke on condition of anonymity, indicate that coach Osbourne has not been present at Thompson-Herah's training sessions for approximately a week.
The specific reason for the split has not been disclosed, but speculation is that both parties could not agree on remuneration.
Coach Osbourne orchestrated the sprinter's late season come-back after the fastest woman alive struggled with an Achilles tendon injury, which saw her placing fifth in the 100m final with 11.06 seconds at the National Championship July 7, to make the relay squad.
Subsequently splitting an impressive 9.93 seconds on the backstretch in the semi-finals of the sprint relay for Jamaica at the World Championship in Budapest, Thompson-Herah put together a string of four impressive races.
Thompson-Herah lowered her season best to 11 seconds flat on August 31 in Zürich, then 10.92 seconds in Bellinzona, Switzerland on September 4. She then clocked 10.84 seconds at the Brussels Diamond League meet on September 8, before ending the season with 10.79 seconds on September 16 at the Prefontaine Classic in Eugene, Oregon.