Second place Waterhouse, who are three points ahead of champions Harbour View, will be at home to the Stars of the East in Sunday’s feature Digicel Premier encounter.
Harbour View have two wins in their last four games while Waterhouse are still searching for a victory.
The teams played to a one-all draw in the first round and Waterhouse's assistant coach Xavier Gilbert say they will brace themselves for another tough battle.
First end of round champions Tivoli Gardens will be hoping to end their two-game winless streak when they host Humble Lion at the Edward Seaga Sports Complex starting at 5:00 pm.
Arnett Gardens will be hoping to stretch their unbeaten run under coach Paul ‘Tegat’ Davis when they play away to Sporting Central Academy at 3:00 pm.
Arnett are fresh from their two-nil win over neighbours Boys Town and coach Davis is eyeing another win on the road.
Boys Town face a tricky tie away to the plucky Reno at Frome, while Village United will have a stern test against newly promoted Benfica at Jarrett Park starting at six o’clock.
Portmore United could close to within three points of the leaders with victory over rock bottom St. Georges at Ferdi Neita Park at 6:30.